Search on: I-KAPPA B PROTEINS 
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Descriptor English:   I-kappa B Proteins 
Descriptor Spanish:   Proteínas I-kappa B 
Descriptor Portuguese:   Proteínas I-kappa B 
Tree Number:   D12.644.360.378
D12.776.260.420
D12.776.476.381
D12.776.930.326
Definition English:   A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. 
See Related English:   I-kappa B Kinase
NF-kappa B
Proto-Oncogene Proteins c-rel
 
History Note English:   2006(2000) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   34471 
Unique Identifier:   D020672 

Occurrence in VHL: 		 

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